Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1
M Oikawa, M Abe, H Kurosawa, W Hida… - Biochemical and …, 2001 - Elsevier
M Oikawa, M Abe, H Kurosawa, W Hida, K Shirato, Y Sato
Biochemical and biophysical research communications, 2001•ElsevierETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a
common feature in these phenomena. We examined whether hypoxia influenced ETS-1
expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter
analysis revealed that the deletion of− 424 to− 279 bp from the human ETS-1 promoter
decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive
element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded …
common feature in these phenomena. We examined whether hypoxia influenced ETS-1
expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter
analysis revealed that the deletion of− 424 to− 279 bp from the human ETS-1 promoter
decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive
element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded …
ETS-1 plays an important role in angiogenesis and cancer invasion, and hypoxia is a common feature in these phenomena. We examined whether hypoxia influenced ETS-1 expression. Hypoxia induced ETS-1 in a human bladder cancer cell line, T24, and promoter analysis revealed that the deletion of −424 to −279 bp from the human ETS-1 promoter decreased the hypoxia-mediated inducibility. This region contained a hypoxia responsive element-like sequence, and HIF-1 bound to it under the hypoxic condition. Double-stranded synthetic oligonucleotides of this sequence as a decoy inhibited the hypoxia-mediated induciblity. These results indicate that hypoxia induces ETS-1 via the activity of HIF-1.
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