Human retinal pigment epithelium cell changes and expression of αB-crystallin: a biomarker for retinal pigment epithelium cell change in age-related macular …
S De, DM Rabin, E Salero, PL Lederman… - Archives of …, 2007 - jamanetwork.com
Objective To examine changes in the retinal pigment epithelium (RPE) in eyes with age-
related macular degeneration (AMD) and specifically to characterize αB-crystallin
expression in RPE cells as a biomarker in this disease. Methods Maculae from human
patients diagnosed as having AMD or from age-matched control eyes were isolated,
cryosectioned, and analyzed immunohistochemically for αB-crystallin and for cell type–
specific markers. Results In eyes with dry and wet AMD, αB-crystallin was heterogeneously …
related macular degeneration (AMD) and specifically to characterize αB-crystallin
expression in RPE cells as a biomarker in this disease. Methods Maculae from human
patients diagnosed as having AMD or from age-matched control eyes were isolated,
cryosectioned, and analyzed immunohistochemically for αB-crystallin and for cell type–
specific markers. Results In eyes with dry and wet AMD, αB-crystallin was heterogeneously …