The 67-kDa laminin-binding protein is involved in shear stress-dependent endothelial nitric-oxide synthase expression
T Gloe, S Riedmayr, HY Sohn, U Pohl - Journal of Biological Chemistry, 1999 - ASBMB
It has been suggested that the mechanical forces acting on endothelial cells may be sensed
in part by cell-matrix connections. We therefore studied the role of different matrix proteins, in
particular laminin I, on a shear stress-dependent endothelial response, namely nitric-oxide
synthase (eNOS) expression. Primary porcine aortic endothelial cells were seeded onto
glass plates either noncoated (NC cells) or precoated with fibronectin (FN cells), laminin (LN
cells), or collagen I (CN cells). Western blots were used to detect differences in the final …
in part by cell-matrix connections. We therefore studied the role of different matrix proteins, in
particular laminin I, on a shear stress-dependent endothelial response, namely nitric-oxide
synthase (eNOS) expression. Primary porcine aortic endothelial cells were seeded onto
glass plates either noncoated (NC cells) or precoated with fibronectin (FN cells), laminin (LN
cells), or collagen I (CN cells). Western blots were used to detect differences in the final …
