Phosphatidylinositol 3-kinase (PI3K) inhibitors as anticancer drugs
JC Verheijen, A Zask - Drugs Future, 2007 - access.portico.org
Abstract The phosphatidylinositol 3-kinases (PI3Ks) are members of a family of lipid kinases
that regulate cellular metabolism and growth by phosphorylation of the 3-position of
phosphatidylinositol to generate phosphatidylinositol triphosphate (PIP3). The PI3K pathway
is one of the most frequently mutated in human cancer, leading to amplification of signaling,
and as such is a promising target for small-molecule inhibition, with exciting therapeutic
opportunities for the treatment of cancer. The last several years have seen an explosive …
that regulate cellular metabolism and growth by phosphorylation of the 3-position of
phosphatidylinositol to generate phosphatidylinositol triphosphate (PIP3). The PI3K pathway
is one of the most frequently mutated in human cancer, leading to amplification of signaling,
and as such is a promising target for small-molecule inhibition, with exciting therapeutic
opportunities for the treatment of cancer. The last several years have seen an explosive …
