[HTML][HTML] Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function
To explore the basis of metastasis, we compared the human breast cancer lines MCF-7 and
MDA-MB453, which have low invasive ability, with their sublines MCF7-I4 and MDA-MB453-
I4 with high invasive ability for gene expression and signaling pathways. We previously
showed that the I4 lines had dramatically elevated levels of Twist compared with their
parental lines. In this study, we observed significantly increased STAT3 Tyr 705
phosphorylation, but not the STAT3 protein levels, in the I4 lines. Activation of STAT3 by …
MDA-MB453, which have low invasive ability, with their sublines MCF7-I4 and MDA-MB453-
I4 with high invasive ability for gene expression and signaling pathways. We previously
showed that the I4 lines had dramatically elevated levels of Twist compared with their
parental lines. In this study, we observed significantly increased STAT3 Tyr 705
phosphorylation, but not the STAT3 protein levels, in the I4 lines. Activation of STAT3 by …