[HTML][HTML] Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related …
Y Li, L He, N Zeng, D Sahu, E Cadenas… - Journal of Biological …, 2013 - ASBMB
Mitochondrial abnormalities are associated with cancer development, yet how oncogenic
signals affect mitochondrial functions has not been fully understood. In this study, we
investigate the relationship between mitochondrial alterations and PI3K/protein kinase B
(AKT) signaling activation using hepatocytes and liver tissues as our experimental models.
We show here that liver-specific deletion of Pten, which leads to activation of PI3K/AKT, is
associated with elevated oxidative stress, increased mitochondrial mass, and augmented …
signals affect mitochondrial functions has not been fully understood. In this study, we
investigate the relationship between mitochondrial alterations and PI3K/protein kinase B
(AKT) signaling activation using hepatocytes and liver tissues as our experimental models.
We show here that liver-specific deletion of Pten, which leads to activation of PI3K/AKT, is
associated with elevated oxidative stress, increased mitochondrial mass, and augmented …