Mechanisms of fidelity in pre-mRNA splicing
R Reed - Current opinion in cell biology, 2000 - Elsevier
R Reed
Current opinion in cell biology, 2000•ElsevierThe pre-mRNA splicing machinery consists of five small nuclear RNAs (U1, U2, U4, U5 and
U6) and more than fifty proteins. Over the past year, important advances have been made in
understanding how these factors function to achieve fidelity in splicing. Of particular note
were the discoveries that the splicing factor U2AF35 recognizes the AG dinucleotide at the
3′ splice site early in spliceosome assembly, that a DEAD-box ATPase, Prp28, triggers
specific rearrangements of the spliceosome, and that the splicing factor hSlu7 functions in …
U6) and more than fifty proteins. Over the past year, important advances have been made in
understanding how these factors function to achieve fidelity in splicing. Of particular note
were the discoveries that the splicing factor U2AF35 recognizes the AG dinucleotide at the
3′ splice site early in spliceosome assembly, that a DEAD-box ATPase, Prp28, triggers
specific rearrangements of the spliceosome, and that the splicing factor hSlu7 functions in …
The pre-mRNA splicing machinery consists of five small nuclear RNAs (U1, U2, U4, U5 and U6) and more than fifty proteins. Over the past year, important advances have been made in understanding how these factors function to achieve fidelity in splicing. Of particular note were the discoveries that the splicing factor U2AF35 recognizes the AG dinucleotide at the 3′ splice site early in spliceosome assembly, that a DEAD-box ATPase, Prp28, triggers specific rearrangements of the spliceosome, and that the splicing factor hSlu7 functions in the fidelity of AG choice during catalytic step II of splicing.
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