[HTML][HTML] Genetic analyses of DNA methyltransferase genes in mouse model system
M Okano, E Li - The Journal of nutrition, 2002 - Elsevier
DNA methylation regulates important biological processes and is involved in tumorigenesis
and several human diseases, such as Rett and immunodeficiency, centromeric instability
and facial anomalies (ICF). The major objective of our research is to investigate the roles of
DNA methylation in mammals through genetic analysis of DNA methyltransferase genes in
mouse and human. Previously, we found that Dnmt1 knockout embryonic stem (ES) cells are
capable of methylating retroviral DNA de novo. In search of enzymes responsible for de …
and several human diseases, such as Rett and immunodeficiency, centromeric instability
and facial anomalies (ICF). The major objective of our research is to investigate the roles of
DNA methylation in mammals through genetic analysis of DNA methyltransferase genes in
mouse and human. Previously, we found that Dnmt1 knockout embryonic stem (ES) cells are
capable of methylating retroviral DNA de novo. In search of enzymes responsible for de …