Evolution of microRNAs located within Hox gene clusters
A Tanzer, CT Amemiya, CB Kim… - Journal of Experimental …, 2005 - Wiley Online Library
Journal of Experimental Zoology Part B: Molecular and …, 2005•Wiley Online Library
MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an
important function in post‐transcriptional gene regulation and in particular modulate the
expression of developmentally important transcription factors including Hox genes. Two
families of microRNAs are genomically located in intergenic regions in the Hox clusters of
vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely
follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster …
important function in post‐transcriptional gene regulation and in particular modulate the
expression of developmentally important transcription factors including Hox genes. Two
families of microRNAs are genomically located in intergenic regions in the Hox clusters of
vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely
follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster …
Abstract
MicroRNAs (miRNAs) form an abundant class of non‐coding RNA genes that have an important function in post‐transcriptional gene regulation and in particular modulate the expression of developmentally important transcription factors including Hox genes. Two families of microRNAs are genomically located in intergenic regions in the Hox clusters of vertebrates. Here we describe their evolution in detail. We show that the micro RNAs closely follow the patterns of protein evolution in the Hox clusters, which is characterized by cluster duplications followed by differential gene loss. J. Exp. Zool. (Mol. Dev. Evol.) 304B: 1–10, 2005. © 2005 Wiley‐Liss, Inc.
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