The Ewing family of tumors: Ewing's sarcoma and primitive neuroectodermal tumors

HE Grier - Pediatric Clinics of North America, 1997 - Elsevier
The Ewing family of tumors (Ewing's sarcoma and primitive neuroectodermal tumor [PNET])
is the second most common malignant bone tumor (after osteogenic sarcoma) in children
and adolescents. These tumors can also occur in soft tissue, presenting in a manner similar
to rhabdomyosarcoma. Nearly half of all patients with Ewing's family tumors are between 10
and 20 years of age, and 70% are under the age of 20, with a slight male predominance.
The annual incidence in the United States is 2.1 cases per million children. 81 A similar …