[HTML][HTML] Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesis
L Lundin, H Larsson, J Kreuger, S Kanda… - Journal of Biological …, 2000 - ASBMB
Fibroblast growth factors (FGFs) are known to induce formation of new blood vessels,
angiogenesis. We show that FGF-induced angiogenesis can be modulated using selectively
desulfated heparin. Chinese hamster ovary cells (CHO677) deficient in heparan sulfate
biosynthesis were employed to assess the function of heparin/heparan sulfate in FGF
receptor-1 (FGFR-1) signal transduction and biological responses. In the presence of FGF-2,
FGFR-1 kinase and subsequent mitogen-activated protein kinase Erk2 activities were …
angiogenesis. We show that FGF-induced angiogenesis can be modulated using selectively
desulfated heparin. Chinese hamster ovary cells (CHO677) deficient in heparan sulfate
biosynthesis were employed to assess the function of heparin/heparan sulfate in FGF
receptor-1 (FGFR-1) signal transduction and biological responses. In the presence of FGF-2,
FGFR-1 kinase and subsequent mitogen-activated protein kinase Erk2 activities were …