Effector T cell plasticity: flexibility in the face of changing circumstances
KM Murphy, B Stockinger - Nature immunology, 2010 - nature.com
Nature immunology, 2010•nature.com
As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning
to be recognized. Components that control the plasticity of CD4 T cell populations include
cellular conditions, clonality, transcriptional circuitry and chromatin modifications.
Appearance of cellular flexibility may arise from truly flexible genetic programs or,
alternatively, from heterogeneous populations. New tools will be needed to define the rules
that allow or prohibit cellular transitions.
to be recognized. Components that control the plasticity of CD4 T cell populations include
cellular conditions, clonality, transcriptional circuitry and chromatin modifications.
Appearance of cellular flexibility may arise from truly flexible genetic programs or,
alternatively, from heterogeneous populations. New tools will be needed to define the rules
that allow or prohibit cellular transitions.
Abstract
As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.
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