Hematopoietic development and homeostasis are based on hematopoietic stem cells
(HSCs), a pool of ancestor cells characterized by the unique combination of self-renewal
and multilineage potential. These two opposing forces are finely orchestrated by several
regulatory mechanisms, comprising both extrinsic and intrinsic factors. Over the past
decades, several studies have contributed to dissect the key role of niche factors, signaling
transduction pathways, and transcription factors in HSC development and maintenance …