Insulin resistance often occurs with dyslipidemia as part of the metabolic syndrome and the
current dominant paradigm is that insulin resistance leads to dyslipidemia. However,
dyslipidemia may also cause insulin resistance; this was postulated 30 years ago, but has
never been substantiated. Establishing whether dyslipidemia plays a causal role in the
etiology of insulin resistance is important since it could reveal new avenues for combating
type 2 diabetes. In this review we summarize recent evidence from epidemiological, genetic …