[HTML][HTML] Steroid receptor coactivator (SRC) family: masters of systems biology
B York, BW O'Malley - Journal of Biological Chemistry, 2010 - ASBMB
The three members of the p160 family of steroid receptor coactivators (SRC-1, SRC-2, and
SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic
rheostats for diverse physiological processes. Since their discovery∼ 15 years ago, the
extraordinary sum of examination of SRC function has shaped the foundation of our
knowledge for the now 350+ coregulators that have been identified to date. In this
perspective, we retrace our steps into the field of coregulators and provide a summary of …
SRC-3) steer the functional output of numerous genetic programs and serve as pleiotropic
rheostats for diverse physiological processes. Since their discovery∼ 15 years ago, the
extraordinary sum of examination of SRC function has shaped the foundation of our
knowledge for the now 350+ coregulators that have been identified to date. In this
perspective, we retrace our steps into the field of coregulators and provide a summary of …