Disruption of the TSLP-TSLPR-LAP signaling between epithelial and dendritic cells through hyperlipidemia contributes to regulatory T-Cell defects in atherosclerotic …
K Yu, Q Dong, X Mao, K Meng, X Zhao, Q Ji, B Wu… - Atherosclerosis, 2015 - Elsevier
Abstract Regulatory T-Cells (Tregs) play a protective role against the development of
atherosclerosis. Moreover, thymic stromal lymphopoietin (TSLP)/thymic stromal
lymphopoietin receptor (TSLPR) signaling in myeloid dendritic cells (DCs) promote Treg
differentiation. Here, we examined the potential role of TSLP/TSLPR on Treg homeostasis in
atherosclerosis. The frequencies of both latency-associated peptide (LAP)+ and Foxp3+
Tregs were reduced in the thymus and spleen of ApoE−/− mice compared with C57BL/6 …
atherosclerosis. Moreover, thymic stromal lymphopoietin (TSLP)/thymic stromal
lymphopoietin receptor (TSLPR) signaling in myeloid dendritic cells (DCs) promote Treg
differentiation. Here, we examined the potential role of TSLP/TSLPR on Treg homeostasis in
atherosclerosis. The frequencies of both latency-associated peptide (LAP)+ and Foxp3+
Tregs were reduced in the thymus and spleen of ApoE−/− mice compared with C57BL/6 …