EGF–ERBB signalling: towards the systems level

A Citri, Y Yarden - Nature reviews Molecular cell biology, 2006 - nature.com
A Citri, Y Yarden
Nature reviews Molecular cell biology, 2006nature.com
Signalling through the ERBB/HER receptors is intricately involved in human cancer and
already serves as a target for several cancer drugs. Because of its inherent complexity, it is
useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which
shares modularity, redundancy and control circuits with robust biological and engineered
systems. Because network fragility is an inevitable trade-off of robustness, systems-level
understanding is expected to generate therapeutic opportunities to intercept aberrant …
Abstract
Signalling through the ERBB/HER receptors is intricately involved in human cancer and already serves as a target for several cancer drugs. Because of its inherent complexity, it is useful to envision ERBB signalling as a bow-tie-configured, evolvable network, which shares modularity, redundancy and control circuits with robust biological and engineered systems. Because network fragility is an inevitable trade-off of robustness, systems-level understanding is expected to generate therapeutic opportunities to intercept aberrant network activation.
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