Virosomal influenza-vaccine induced immunity in HIV-infected individuals with high versus low CD4+ T-cell counts: clues towards a rational vaccination strategy
S Fritz, E Mossdorf, B Durovic, G Zenhaeusern… - Aids, 2010 - journals.lww.com
S Fritz, E Mossdorf, B Durovic, G Zenhaeusern, A Conen, I Steffen, M Battegay, R Nüesch…
Aids, 2010•journals.lww.comIn a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4+
T-cell counts less than 350 μl were distinct from HIV-infected individuals with more than 350
CD4+ T-cell counts/μl, and from HIV-negative individuals, in that an influenza-specific
immunoglobulin M-response was absent and expansion of interferon-γ-secreting CD4+ T
cells was impaired. By contrast, immunoglobulin G-responses were induced in all study
groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B …
T-cell counts less than 350 μl were distinct from HIV-infected individuals with more than 350
CD4+ T-cell counts/μl, and from HIV-negative individuals, in that an influenza-specific
immunoglobulin M-response was absent and expansion of interferon-γ-secreting CD4+ T
cells was impaired. By contrast, immunoglobulin G-responses were induced in all study
groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B …
Abstract
In a prospective influenza-vaccination trial we show that HIV-infected individuals with CD4+ T-cell counts less than 350 μl were distinct from HIV-infected individuals with more than 350 CD4+ T-cell counts/μl, and from HIV-negative individuals, in that an influenza-specific immunoglobulin M-response was absent and expansion of interferon-γ-secreting CD4+ T cells was impaired. By contrast, immunoglobulin G-responses were induced in all study groups. These data suggest that establishing broad influenza-specific (immunoglobulin G) B-cell memory prior to severe immunodeficiency is important.
Lippincott Williams & Wilkins