The proprotein convertase PCSK9 induces the degradation of low density lipoprotein receptor (LDLR) and its closest family members VLDLR and ApoER2
S Poirier, G Mayer, S Benjannet, E Bergeron… - Journal of Biological …, 2008 - ASBMB
The proprotein convertase PCSK9 gene is the third locus implicated in familial
hypercholesterolemia, emphasizing its role in cardiovascular diseases. Loss of function
mutations and gene disruption of PCSK9 resulted in a higher clearance of plasma low
density lipoprotein cholesterol, likely due to a reduced degradation of the liver low density
lipoprotein receptor (LDLR). In this study, we show that two of the closest family members to
LDLR are also PCSK9 targets. These include the very low density lipoprotein receptor …
hypercholesterolemia, emphasizing its role in cardiovascular diseases. Loss of function
mutations and gene disruption of PCSK9 resulted in a higher clearance of plasma low
density lipoprotein cholesterol, likely due to a reduced degradation of the liver low density
lipoprotein receptor (LDLR). In this study, we show that two of the closest family members to
LDLR are also PCSK9 targets. These include the very low density lipoprotein receptor …
