Interleukin-17 and type 17 helper T cells
P Miossec, T Korn, VK Kuchroo - New England Journal of …, 2009 - Mass Medical Soc
P Miossec, T Korn, VK Kuchroo
New England Journal of Medicine, 2009•Mass Medical SocType 17 helper T cells (Th17)—a third class of T cells—and their major cytokine, interleukin-
17, are essential for the defense against certain fungi, extracellular bacteria, and
Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17
are prominent in chronic inflammation and several immunoinflammatory disorders.
Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in
clinical trials.
17, are essential for the defense against certain fungi, extracellular bacteria, and
Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17
are prominent in chronic inflammation and several immunoinflammatory disorders.
Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in
clinical trials.
Type 17 helper T cells (Th17) — a third class of T cells — and their major cytokine, interleukin-17, are essential for the defense against certain fungi, extracellular bacteria, and Mycobacterium tuberculosis. Defective control of Th17 cells and production of interleukin-17 are prominent in chronic inflammation and several immunoinflammatory disorders. Monoclonal antibodies against cytokines produced by Th17 cells are being investigated in clinical trials.
The New England Journal Of Medicine