[HTML][HTML] SARS–CoV-2 infection of the placenta
H Hosier, SF Farhadian, RA Morotti… - The Journal of …, 2020 - Am Soc Clin Investig
H Hosier, SF Farhadian, RA Morotti, U Deshmukh, A Lu-Culligan, KH Campbell, Y Yasumoto…
The Journal of clinical investigation, 2020•Am Soc Clin InvestigBACKGROUND The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy
remain relatively unknown. We present a case of second trimester pregnancy with
symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.
METHODS We analyzed the placenta for the presence of severe acute respiratory syndrome
coronavirus 2 (SARS–CoV-2) through molecular and immunohistochemical assays and by
and electron microscopy and measured the maternal antibody response in the blood to this …
remain relatively unknown. We present a case of second trimester pregnancy with
symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.
METHODS We analyzed the placenta for the presence of severe acute respiratory syndrome
coronavirus 2 (SARS–CoV-2) through molecular and immunohistochemical assays and by
and electron microscopy and measured the maternal antibody response in the blood to this …
BACKGROUND
The effects of the novel coronavirus disease 2019 (COVID-19) in pregnancy remain relatively unknown. We present a case of second trimester pregnancy with symptomatic COVID-19 complicated by severe preeclampsia and placental abruption.
METHODS
We analyzed the placenta for the presence of severe acute respiratory syndrome coronavirus 2 (SARS–CoV-2) through molecular and immunohistochemical assays and by and electron microscopy and measured the maternal antibody response in the blood to this infection.
RESULTS
SARS–CoV-2 localized predominantly to syncytiotrophoblast cells at the materno-fetal interface of the placenta. Histological examination of the placenta revealed a dense macrophage infiltrate, but no evidence for the vasculopathy typically associated with preeclampsia.
CONCLUSION
This case demonstrates SARS–CoV-2 invasion of the placenta, highlighting the potential for severe morbidity among pregnant women with COVID-19.
FUNDING
Beatrice Kleinberg Neuwirth Fund and Fast Grant Emergent Ventures funding from the Mercatus Center at George Mason University. The funding bodies did not have roles in the design of the study or data collection, analysis, and interpretation and played no role in writing the manuscript.
The Journal of Clinical Investigation