[HTML][HTML] Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication
ER Argañaraz, M Schindler, F Kirchhoff… - Journal of Biological …, 2003 - ASBMB
Three viral proteins participate in the down-modulation of CD4 in human immunodeficiency
virus type 1 (HIV-1)-infected cells. The underlying mechanisms have been extensively
investigated. However, the physiological relevance of this phenomenon remains poorly
understood. To address the role of CD4 down-modulation in HIV-1 pathogenesis in vivo, we
have characterized the functional properties of nef alleles isolated from seven HIV-1-infected
patients at either the stage of AIDS (late alleles) or during the asymptomatic phase of …
virus type 1 (HIV-1)-infected cells. The underlying mechanisms have been extensively
investigated. However, the physiological relevance of this phenomenon remains poorly
understood. To address the role of CD4 down-modulation in HIV-1 pathogenesis in vivo, we
have characterized the functional properties of nef alleles isolated from seven HIV-1-infected
patients at either the stage of AIDS (late alleles) or during the asymptomatic phase of …