Il-10 deficient mice express IFN-γ mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice
AA Devlin, PJ Halvorsen, JC Miller, SM Laster - Immunobiology, 2017 - Elsevier
Abstract Leptospira interrogans (L. interrogans), the causative agent of leptospirosis, is a
widespread zoonotic spirochete that lives a dual lifestyle. L. interrogans infects mice, rats,
and wildlife in a persistent and asymptomatic fashion, while also causing productive and
acute infections in other mammals such as humans and hamsters. Infections in humans can
be fatal, accompanied by a cytokine storm and shock-like symptoms. Production of IL-10 has
been noted in both rodent and human infections which has led a number of investigators to …
widespread zoonotic spirochete that lives a dual lifestyle. L. interrogans infects mice, rats,
and wildlife in a persistent and asymptomatic fashion, while also causing productive and
acute infections in other mammals such as humans and hamsters. Infections in humans can
be fatal, accompanied by a cytokine storm and shock-like symptoms. Production of IL-10 has
been noted in both rodent and human infections which has led a number of investigators to …