Immunological profiles in HIV positive patients following HAART initiation in Kigali, Rwanda
AP Twizerimana, J Mwatha, JP Musabyimana… - East African Medical …, 2014 - ajol.info
AP Twizerimana, J Mwatha, JP Musabyimana, E Kayigi, JDD Harelimana, SM Karanja…
East African Medical Journal, 2014•ajol.infoBackground: Interleukin-10, IL-2 and IFN-γ are some of the crucial cytokines associated with
HIV infection and pathogenesis. While IL-2 and IFN-γ play critical roles in host resistance to
infection, IL-10 inhibits the synthesis IFN-γ, IL-2 at mRNA and protein level; exacerbating
damage to immune system. Objective: To determine the levels of, changes in and correlation
between CD4 count, viral load, IL-10, IL-2 and IFN-γ before HAART and at six months of
HAART among HIV positive patients in Kigali; with a view to understand cytokine networks …
HIV infection and pathogenesis. While IL-2 and IFN-γ play critical roles in host resistance to
infection, IL-10 inhibits the synthesis IFN-γ, IL-2 at mRNA and protein level; exacerbating
damage to immune system. Objective: To determine the levels of, changes in and correlation
between CD4 count, viral load, IL-10, IL-2 and IFN-γ before HAART and at six months of
HAART among HIV positive patients in Kigali; with a view to understand cytokine networks …
Abstract
Background: Interleukin-10, IL-2 and IFN-γ are some of the crucial cytokines associated with HIV infection and pathogenesis. While IL-2 and IFN-γ play critical roles in host resistance to infection, IL-10 inhibits the synthesis IFN-γ, IL-2 at mRNA and protein level; exacerbating damage to immune system.
Objective: To determine the levels of, changes in and correlation between CD4 count, viral load, IL-10, IL-2 and IFN-γ before HAART and at six months of HAART among HIV positive patients in Kigali; with a view to understand cytokine networks particularly in relation to HAART; and to see whether they can be used as alternative markers of the disease progression.
Design: Longitudinal study.
Setting: Kagugu, Kimironko, Biryogo, Gitega Health Centres and Centre Medico-Social Cornum; all located in Kigali.
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