Understanding and exploiting the endogenous interleukin-10/STAT3-mediated anti-inflammatory response
PJ Murray - Current opinion in pharmacology, 2006 - Elsevier
Interleukin (IL)-10 performs an irreplaceable role in negatively regulating inflammation,
primarily through a mechanism that selectively blocks the expression of pro-inflammatory
genes encoding cytokines, chemokines, cell-surface molecules and other molecules
involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as
a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory
agent has, however, not met expectations. Nevertheless, the signaling pathway used by the …
primarily through a mechanism that selectively blocks the expression of pro-inflammatory
genes encoding cytokines, chemokines, cell-surface molecules and other molecules
involved in the propagation of inflammation. Not surprisingly, IL-10 has attracted interest as
a tool to regulate inflammatory diseases. The clinical use of IL-10 as an anti-inflammatory
agent has, however, not met expectations. Nevertheless, the signaling pathway used by the …