Abnormal neutrophil traps and impaired efferocytosis contribute to liver injury and sepsis severity after binge alcohol use
Background & Aims Neutrophil extracellular traps (NETs) are an important strategy utilized
by neutrophils to immobilize and kill invading microorganisms. Herein, we studied NET
formation and the process of neutrophil cell death (NETosis), as well as the clearance of
NETs by macrophages (MΦ)(efferocytosis) in acute sepsis following binge drinking.
Methods Healthy volunteers consumed 2 ml of vodka/kg body weight, before blood
endotoxin and 16 s rDNA were measured. Peripheral neutrophils were isolated and …
by neutrophils to immobilize and kill invading microorganisms. Herein, we studied NET
formation and the process of neutrophil cell death (NETosis), as well as the clearance of
NETs by macrophages (MΦ)(efferocytosis) in acute sepsis following binge drinking.
Methods Healthy volunteers consumed 2 ml of vodka/kg body weight, before blood
endotoxin and 16 s rDNA were measured. Peripheral neutrophils were isolated and …
