An image analysis toolbox for high-throughput C. elegans assays
C Wählby, L Kamentsky, ZH Liu, T Riklin-Raviv… - Nature …, 2012 - nature.com
Nature methods, 2012•nature.com
We present a toolbox for high-throughput screening of image-based Caenorhabditis
elegans phenotypes. The image analysis algorithms measure morphological phenotypes in
individual worms and are effective for a variety of assays and imaging systems. This
WormToolbox is available through the open-source CellProfiler project and enables
objective scoring of whole-worm high-throughput image-based assays of C. elegans for the
study of diverse biological pathways that are relevant to human disease.
elegans phenotypes. The image analysis algorithms measure morphological phenotypes in
individual worms and are effective for a variety of assays and imaging systems. This
WormToolbox is available through the open-source CellProfiler project and enables
objective scoring of whole-worm high-throughput image-based assays of C. elegans for the
study of diverse biological pathways that are relevant to human disease.
Abstract
We present a toolbox for high-throughput screening of image-based Caenorhabditis elegans phenotypes. The image analysis algorithms measure morphological phenotypes in individual worms and are effective for a variety of assays and imaging systems. This WormToolbox is available through the open-source CellProfiler project and enables objective scoring of whole-worm high-throughput image-based assays of C. elegans for the study of diverse biological pathways that are relevant to human disease.
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