Novel mutations in genes encoding subcortical maternal complex proteins may cause human embryonic developmental arrest
X Wang, D Song, D Mykytenko, Y Kuang, Q Lv… - Reproductive …, 2018 - Elsevier
Successful human reproduction initiates from normal gamete formation, fertilization and
early embryonic development. Abnormalities in any of these steps will lead to infertility.
Many infertile patients undergo several failures of IVF and intracytoplasmic sperm injection
(ICSI) cycles, and embryonic developmental arrest is a common phenotype in cases of
recurrent failure of IVF/ICSI attempts. However, the genetic basis for this phenotype is poorly
understood. The subcortical maternal complex (SCMC) genes play important roles during …
early embryonic development. Abnormalities in any of these steps will lead to infertility.
Many infertile patients undergo several failures of IVF and intracytoplasmic sperm injection
(ICSI) cycles, and embryonic developmental arrest is a common phenotype in cases of
recurrent failure of IVF/ICSI attempts. However, the genetic basis for this phenotype is poorly
understood. The subcortical maternal complex (SCMC) genes play important roles during …
