GSK3 and its interactions with the PI3K/AKT/mTOR signalling network
Abstract Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and
its phosphorylation of its diverse substrates has major influences on many areas of
physiology and pathology, including cellular metabolism, lineage commitment and
neuroscience. GSK3 was one of the first identified substrates of the heavily studied
oncogenic kinase AKT, phosphorylation by which inhibits GSK3 activity via the formation of
an autoinhibitory pseudosubstrate sequence. This has led to investigation of the role of …
its phosphorylation of its diverse substrates has major influences on many areas of
physiology and pathology, including cellular metabolism, lineage commitment and
neuroscience. GSK3 was one of the first identified substrates of the heavily studied
oncogenic kinase AKT, phosphorylation by which inhibits GSK3 activity via the formation of
an autoinhibitory pseudosubstrate sequence. This has led to investigation of the role of …