[HTML][HTML] Intestinal immunoregulation: lessons from human mendelian diseases
F Charbit-Henrion, M Parlato, G Malamut… - Mucosal …, 2021 - Elsevier
The mechanisms that maintain intestinal homeostasis despite constant exposure of the gut
surface to multiple environmental antigens and to billions of microbes have been scrutinized
over the past 20 years with the goals to gain basic knowledge, but also to elucidate the
pathogenesis of inflammatory bowel diseases (IBD) and to identify therapeutic targets for
these severe diseases. Considerable insight has been obtained from studies based on gene
inactivation in mice as well as from genome wide screens for genetic variants predisposing …
surface to multiple environmental antigens and to billions of microbes have been scrutinized
over the past 20 years with the goals to gain basic knowledge, but also to elucidate the
pathogenesis of inflammatory bowel diseases (IBD) and to identify therapeutic targets for
these severe diseases. Considerable insight has been obtained from studies based on gene
inactivation in mice as well as from genome wide screens for genetic variants predisposing …
