The UNC-45 myosin chaperone: from worms to flies to vertebrates
CF Lee, GC Melkani, SI Bernstein - … review of cell and molecular biology, 2014 - Elsevier
Abstract UNC-45 (uncoordinated mutant number 45) is a UCS (UNC-45, CRO1, She4p)
domain protein that is critical for myosin stability and function. It likely aides in folding myosin
during cellular differentiation and maintenance, and protects myosin from denaturation
during stress. Invertebrates have a single unc-45 gene that is expressed in both muscle and
nonmuscle tissues. Vertebrates possess one gene expressed in striated muscle (unc-45b)
and another that is more generally expressed (unc-45a). Structurally, UNC-45 is composed …
domain protein that is critical for myosin stability and function. It likely aides in folding myosin
during cellular differentiation and maintenance, and protects myosin from denaturation
during stress. Invertebrates have a single unc-45 gene that is expressed in both muscle and
nonmuscle tissues. Vertebrates possess one gene expressed in striated muscle (unc-45b)
and another that is more generally expressed (unc-45a). Structurally, UNC-45 is composed …