Efficacy and safety of topical timolol for the treatment of infantile hemangioma in the early proliferative stage: a randomized clinical trial
FZ Muñoz-Garza, M Ríos, E Roé-Crespo… - JAMA …, 2021 - jamanetwork.com
Importance Treatment of infantile hemangioma (IH) with topical timolol in the first 2 months of
life (early proliferative phase) may prevent further growth and the need for treatment with
oral propranolol. To our knowledge, no studies have determined whether beginning early
treatment with timolol for IH is better than in other proliferative stages. Objective To evaluate
the efficacy and safety of timolol maleate solution, 0.5%, for the early treatment of IH in
infants younger than 60 days. Design, Setting, and Participants This multicenter …
life (early proliferative phase) may prevent further growth and the need for treatment with
oral propranolol. To our knowledge, no studies have determined whether beginning early
treatment with timolol for IH is better than in other proliferative stages. Objective To evaluate
the efficacy and safety of timolol maleate solution, 0.5%, for the early treatment of IH in
infants younger than 60 days. Design, Setting, and Participants This multicenter …
